Millions of American immigrants, who worked in business or started new businesses of their own, also used businesses in order to reach America in the first place. Before the mid nineteenth century advent of the telegraph, railroad and steamship, this migration usually relied on the services of multiple businesses and intermediaries in order to carry out long multi-stage journeys across land and ocean. In the modern “global village,” interconnected by widely available fast air travel, key services needed by international migrants are also generally dispersed across multiple businesses, often related mainly to surmounting and adapting to legal restrictions. In between, during late nineteenth and early twentieth centuries, the business of migration was concentrated mainly on the crossing of the North Atlantic. Mass transatlantic migration then became the core segment of the world’s first major intercontinental travel industry, a business in which large German shipping lines played a leading role. Within a longer term context, this essay emphasizes that middle epoch of commercially-provided physical relocation from Europe to the United States, and also includes a sub-focus on entrepreneurship of German origin.